Isolation, Characterization of dihydroflavonol from Coriandrum sativum Seeds

  • Nosaiba K. Hamed Assistant Professor, Department of Chemistry, Faculty of Education, Omdurman Islamic University
  • Suad A. Gadir Professor of Chemistry, Faculty of Education, Al-zaiem Al-azhary University.


         تم فصل أول مركب فلافوني من بذور نبات الكزبرة ذو الأهمية الطبية .  المستخلص الكحولي أعطي المركب : 7 ، 5  ثنائي  هيدروكسيل - ׳ 5 ميثوكسيل  ثنائي هيدروالفلافونول ، والذي حددت تركيبته بواسطة  طيف الأشعة  تحت   الحمراء ، طيف الأشعة  فوق البنفسجية ، طيف الرنين النووي المغنطيسي و طيف الكتلة .                            


The authors report on the first isolation of a flavone from the seeds of the medicinally important plant Coriandrum sativum (Apiaceae) . Chromatographic fractionation of the ethanolic extract gave flavonoid (C1) : 5,7,–dihydroxy-5׳- methoxy dihydroflavonol.The structure of this compound was elucidated on the basis of its IR, UV,1H NMR and MS.



1. Catherine,A., Rice,E., “ Flavonoids in Health and Disease”Marcel Dekker,New York,2 nd Ed., p 43 (2003).
2. Zechemeister , L., "Progress in The Chemistry of Organic Natural Products" Springer Verlag,New York, p.17,19 (1957).
3. Satyajit, D., Sarker, Zahid ,L. A.,lexander, I., “ Natural Products Isolation” Humana Press , 2 nd Ed.,p252 (2006).
4. Bohm,B., “Introduction to Flavonoids”Harwood Academic,(1992).
5. De Groot, H.,Rauen,V., Fundam. Clin. Pharmacol., 12,249 (1998).
6. Middleton, E. , Kandaswami, C. , Eur. J. Biochem., 176,661 (2000).
7. Hif, CS., Howell. SL.,J. Amer. Coll. Nutr. , 26 , 5 471(2007).
8. El Tahir, A., Satti, G. M. H. and Khalid, S. A., J. Ethnopharmacol., 64, 233 (1999).
9. Kayser, O., Abreu, P. M., Pharmaceutical Biology, 39(4), 288 (2001).
10. Bors, W., Heller, W., Michel. C., Saran, M., Methods Enzymol.,186,343(1990).
11. Colerige, Smith, PO., Thomas, P., Scurr, J.,H., Dormandy, J.,A.,Br., Med., J;296:1726,7(1980).
12. Hegarty ,V.M., May ,H.M., Khaw, K.T., Am. J Clin Nutr., 71,1003 (2000).
13. Wangensteen, Helle; Samuelsen, Anne Berit; Malterud, Karl Egil (2004). "Antioxidant activity in extracts from coriander". Food Chemistry 88 (2): 293
14. Kubo, Isao; Fujita, Ken-Ichi; Kubo, Aya; Nihei, Ken-Ichi; Ogura, Tetsuya (2004). "Antibacterial Activity of Coriander Volatile Compounds
15. Stevenson, Matilda Coxe Ethnobotany of the Zuni Indians. SI-BAE Annual Report .30 .p. 66 (1951) .
16. againstSalmonella choleraesuis". Journal of Agricultural and Food Chemistry 52 (11): 3329–32 (2012) .
17. Ebo, DG; Bridts, CH; Mertens, MH; Stevens, WJ . "Coriander anaphylaxis in a spice grinder with undetected occupational allergy". Acta clinica Belgica 61 (3): 152 (2006) .
18. Gray, Alison M.; Flatt, Peter R. "Insulin-releasing and insulin-like activity of the traditional anti-diabetic plant Coriandrum sativum (coriander)". British Journal of Nutrition 81 (3): 203–209(2007).
19. Eidi, M; Eidi, A; Saeidi, A; Molanaei, S; Sadeghipour, A; Bahar, M; Bahar, K. "Effect of coriander seed (Coriandrum sativum L.) ethanol extract on insulin release from pancreatic beta cells in streptozotocin-induced diabetic rats". Phytotherapy Research 23 (3): 404–6(2009).
20. Jump up ^ Chithra, V.; Leelamma, S. "Hypolipidemic effect of coriander seeds (Coriandrum sativum): Mechanism of action". Plant Foods for Human Nutrition 51 (2): 167–72(1997).
21. Bauer, A.W., Kirby, W.M.,Sherris,J.C., Jurck, M.Antibiotic susceptibility testing by standared singl diesc method. Am.J.J.Clin patho, 51,493-496 (1996).
How to Cite
K. HAMED, Nosaiba; A. GADIR, Suad. Isolation, Characterization of dihydroflavonol from Coriandrum sativum Seeds. Gezira Journal of Health Sciences, [S.l.], v. 14, n. 2, dec. 2018. ISSN 1810-5386. Available at: <>. Date accessed: 18 sep. 2019.