Effect of Watermelon Juice Consumption on Brachial Blood Pressure among Sudanese Hypertensive Patients

Amna Abdalla BabikerAli

  • Amna Abdalla BabikerAli



Watermelon is a rich source of L-arginine and L-citrulline. L-arginine is the sole substrate of endothelial nitric oxide synthase (eNOS) producing nitric oxide (NO) and L-citrulline. NO is a vasodilator and muscle relaxant. L-arginine is also catabolized by arginase into L-ornithine and urea.The ratio of arginine to its catabolic products, L- citrulline and L-ornithine, accounts to its bioavailability. It has been reported that diminished global arginine bioavailability ratio (GABR) increases the risk of cardiovascular diseases and has been considered as a biomarker for coronary artery diseases. Encouraged by the seek of alternative non-pharmacological hypotensive agents, the effect of watermelon juice supplement was studied among 31 stage 1 hypertensive Sudanese patients. Exclusion criteria included pregnancy, metabolic diseases, diabetes, liver, kidney and cardiovascular diseases. Participants received one liter of freshly prepared watermelon juice daily for three weeks (L-citrulline/L-arginine:1g/0.5g per day). Results showed that watermelon juice supplement significantly increases plasma L-arginine, L-citrulline and L-ornithine levels and reduced brachial blood pressure and global arginine bioavailability ratio. In conclusion, we suggest that watermelon juice could be used as a potential natural hypotensive agent even at low doses. Although watermelon juice increases plasma arginine level, GABR may not be a useful biomarker to assess the progression of hypertension.

How to Cite
BABIKERALI, Amna Abdalla. Effect of Watermelon Juice Consumption on Brachial Blood Pressure among Sudanese Hypertensive Patients. Gezira Journal of Health Sciences, [S.l.], v. 12, n. 2, dec. 2016. ISSN 1810-5386. Available at: <http://journals.uofg.edu.sd/index.php/gjhs/article/view/46>. Date accessed: 29 feb. 2020.